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New insights into the control of inflammation – EurekAlert

Wistar scientists discovered that EGR1inhibits expression of pro-inflammatory genes in macrophages. The discovery expands the understanding of how macrophages are…



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IMAGE: Dr. Gardini (Center) in the lab.
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Credit: The Wistar Institute
PHILADELPHIA — (Jan. 13, 2021) — Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. As part of their function to protect the body against pathogens, macrophages play a major role in initiation, maintenance, and resolution of inflammation. The discovery…

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