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Pediatric Osteosarcoma and Pathogenic TP53 Variants – www.oncnursingnews.com/

TP53 was found to be the only gene with a germline de novo pathogenic or likely pathogenic variant in pediatric patients with osteosarcoma, according to finding…

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TP53 was found to be the only gene with a germline de novo pathogenic or likely pathogenic variant in pediatric patients with osteosarcoma, according to findings from the Children’s Oncology Group that were published in JCO Precision Oncology.Among 95 pediatric patients with osteosarcoma who underwent whole-exome sequencing, 61 de novo variants were identified in 60 genes (n = 47). Among all 240 pediatric patients with osteosarcoma, 5.4% (n = 13) harbored a pathogenic or likely pathogenic TP53 g…

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