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Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity – Science Magazine

Among the coronaviruses that infect humans, four cause mild common colds, whereas three others, including the currently circulating severe acute respiratory syndrome…



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Cornaviruses constitute a large family of enveloped, positive-sense single-stranded RNA viruses that cause diseases in birds and mammals (1). Among the strains that infect humans are the alphacoronaviruses HCoV-229E and HCoV-NL63 and the betacoronaviruses HCoV-OC43 and HCoV-HKU1, which cause common colds (Fig. 1A). Three additional betacoronavirus species result in severe infections in humans: severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus…

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